Cooperative binding processes are widespread in Nature and are important for regulation of key enzymes and receptors. In general, cooperativity is controlled by an allosteric response to ligand ...

The alternative text for this image may have been generated using AI. Figure 2: Temperature dependence of AAC(6′)-Ii binding thermodynamics and secondary structure. The alternative text for this image ...

Antimicrobial resistance (AMR) is a global health problem. Species of drug-resistant pathogens, including Neisseria gonorrhoeae, could become untreatable due to a high degree of AMR. A team of ...

Screening new drugs/compounds in the presence of a known enzyme allosteric inhibitor (CoSPI method) improves chances of drug development for many new diseases. To discover new therapeutic uses of ...