Figure 1: Translocation and backtracking for RNA Pol II Elongation Complex (EC). In this study, we built a MSM to investigate the mechanisms of Pol II backtracking upon nucleotide mis-incorporation, a ...

Figure 1: RNA polymerase transcription and proofreading studied by optical trapping. We studied transcription by RNAP at physiological nucleotide concentrations using a new single-molecule assay ...

A technique can determine for the first time how frequently, and exactly where, a molecular event called 'backtracking' occurs throughout the genetic material (genome) of any species. A technique can ...

A technique can determine for the first time how frequently, and exactly where, a molecular event called "backtracking" occurs throughout the genetic material (genome) of any species, a new study ...