Glucocorticoids are the consensus treatment for the prevention of respiratory distress in preterm infants, but there is evidence for increased incidence of neurodevelopmental disorders as a result of ...

Brain region-specific organoids have allowed researchers to peer inside the complex programming of human forebrain development, a process once inaccessible to molecular study. The results bring new ...

Researchers of the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch have now identified and described a molecular mechanism underlying the most common malformation of the brain in humans.

Some say that out of all the objects in the universe, the human brain is the most complex. Much of what makes us uniquely human — our emotions, memories, consciousness — stems from this 3-pound organ, ...

Two independent research teams have successfully regenerated mouse brain circuits in mice using neurons grown from rat stem cells. Both studies, using interspecies blastocyst complementation to study ...

斑马鱼中BMP4诱导模型揭示HPE相关眼表型谱及其分子机制。通过调整诱导时间，观察到从先天性无眼球症到眼裂融合、小眼等连续眼表型，并发现BMP4通过影响视网膜前体细胞形态重塑（如基底部收缩）和晶体蛋白基因（cryaa）表达异常导致不同表型。基因表达分析 ...

During the development of vertebrate forebrain the formation of anterior neural structures requires suppression of Wnt signals originating from the paraxial mesoderm and midbrain territory. However, ...