Molecular and cellular mechanisms of epithelial–mesenchymal transition (EMT), crucial in development and pathogenesis, are still poorly understood. Here we provide evidence that distinct cellular ...

In their publication in Science, Professor Guojun Sheng (Kumamoto University, Japan), Professor Alfonso Martinez Arias (Universidad Pompeu Fabra, Spain) and Professor Ann Sutherland (University of ...

Researchers offer a phylogenetic and ontogenetic overview of the primitive streak and its role in mediating amniote (vertebrate animals that develop on land) gastrulation, and discuss the implications ...

Uniting three different parameters in single cells taken from mouse embryos reveals more about how foundational cell identities are established in early development The first single-cell multi-omics ...

With the construction of a building, one of the first steps before creating the upright structure is to set the foundations and the floorplan. Mammalian development is not so different. A ...

Scientists from Helmholtz Zentrum München revise the current textbook knowledge about gastrulation, the formation of the basic body plan during embryonic development. Their study in mice has ...

As a human embryo grows, a set of molecules directs cells as they multiply and take on specific identities and spatial positions within the embryo. In one crucial step known as gastrulation, these ...

An embryo-like model researchers created from stem cells can provide a 'blueprint' of the human body as it forms, a study has reported. The development by researchers from the University of Cambridge ...