Genic variants are more likely to alter gene function and affect disease risk than those that occur outside genes. Variants in genes, however, might not be sufficiently covered by the existing ...

One of the main goals of the Human Genome Project (see Online links box) was to identify all the functional elements of the human genome. It was initially predicted that most human DNA does not have a ...

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Several evolutionary biologists have used a parsimony argument to argue that the single gene is the unit of selection. Since all evolution by natural selection can be represented in terms of selection ...