在真核生物中，调控性ncRNA的发现路径较为曲折。1990年，首个长非编码RNA（lncRNA）H19被鉴定，其虽具mRNA特征却无编码能力，并证实对胚胎发育至关重要。然而，真核小RNA的存在直至1993年才通过线虫中的lin-4 RNA得以揭示，其通过靶向mRNA的3‘UTR抑制翻译。随后let-7 ...

The study shows that a long non-coding RNA called CISTR-ACT acts as a master regulator of cell size, influencing how large or small cells grow across multiple tissues.

Schematic representation summarising MASLD-associated long non-coding RNAs (lncRNAs) and their relevant targets in hepatocytes: human leukocyte antigen (HLA) complex group 18 (HCG18), nuclear enriched ...

Researchers uncover a cunning new trick by which breast cancer cells evade immune attack. While the cGAS-STING pathway normally detects cytosolic DNA and activates anti-tumor immunity via ...

These genes are part of the non-coding genome, which makes up about 98% of our DNA and was long dismissed as “junk.” This new ...

What keeps our cells the right size? Scientists have long puzzled over this fundamental question, since cells that are too large or too small are linked to many diseases. Until now, the genetic basis ...