总的来说，这项研究提供了大脑皮层中大量的 lncRNA 和 circRNA 及其相应的顺式表达数量性状基因座（cis-eQTL），这有助于更深入地理解大脑皮层中基因表达的遗传调控，并弥合大脑相关疾病遗传关联与其病理生理机制之间的差距。
我们的身体如同一个精密的“细胞社会”，每个细胞的大小与形态都需严格把控。这项研究不仅让我们看到，那些曾被忽视的“基因组暗物质”其实是细胞世界的“隐形指挥官”，也为未来从非编码RNA角度理解疾病、开发新疗法点亮了一盏灯。或许在不久的将来，我们能通过调节这些“细胞尺寸开关”，为贫血、发育障碍乃至癌症患者带来新的希望。（ 生物谷 Bioon.com） ...
在真核生物中，调控性ncRNA的发现路径较为曲折。1990年，首个长非编码RNA（lncRNA）H19被鉴定，其虽具mRNA特征却无编码能力，并证实对胚胎发育至关重要。然而，真核小RNA的存在直至1993年才通过线虫中的lin-4 RNA得以揭示，其通过靶向mRNA的3‘UTR抑制翻译。随后let-7 ...
What keeps our cells the right size? Scientists have long puzzled over this fundamental question, since cells that are too ...
Interesting Engineering on MSN
Scientists identify a non-coding gene that directly controls how big cells grow
The study shows that a long non-coding RNA called CISTR-ACT acts as a master regulator of cell size, influencing how large or ...
Cancer is most treatable in its early stages, so finding innovative and non-invasive methods to diagnose cancer early on is crucial for fighting the disease. Liquid biopsies, which require just a ...
SickKids researchers discovered that a long non-coding RNA, CISTR-ACT, directly regulates cell size. Using gene-editing tools ...
Profiling noncoding repetitive RNA sequences improves the sensitivity of liquid biopsy diagnostic tests for early stage cancers. As cancer is most treatable in its early stages, developing diagnostic ...
一些您可能无法访问的结果已被隐去。
显示无法访问的结果
反馈