Spatial transcriptomics provides a unique perspective on the genes that cells express and where those cells are located. However, the rapid growth of the technology has come at the cost of ...

This article explores how researchers are using spatially resolved methods to explore diverse biological processes from ...

Scientists at Duke-NUS Medical School have developed two powerful computational tools that could transform how researchers ...

Spatial transcriptomics offers a revolutionary approach to understanding the tumor microenvironment (TME) in solid tumors by preserving the spatial context of gene expression, which is crucial for ...

This article explores how single-cell multiomics and spatial transcriptomics are illuminating early pregnancy, uncovering ...

Delaram Pouyabahar is a Canadian based computational biologist whose planned postdoctoral move to Harvard University ...

Plants form a critical model for understanding regulated cell death (RCD) as part of their sophisticated immune responses. In the ongoing evolutionary arms ...

The diagnostic armamentarium for solid tumors is evolving rapidly, redefining how we detect, stage, stratify, monitor, and ultimately treat cancer. This ...

这就好比为了研究一座摩天大楼的内部结构，我们不得不把它切成一张张薄纸。虽然每张纸上的信息都看清了，但楼层的连接、电梯的走向、房间的立体空间感统统丢失了。更糟糕的是，切片过程本身就会把细胞“腰斩”，导致RNA丢失。

引言生命的诞生是一场宏大而精密的折叠游戏。从一个受精卵开始，细胞不仅要分裂，还要在极其精确的时间和空间节点上进行大规模的迁移、挤压和重排，最终“自组织”成具有复杂功能的立体组织。这或许是发育生物学中最大的未解之谜：一团看似混沌的细胞，究竟遵循着怎样的 ...