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Abstract: We propose a systematic approach that leverages automatic differentiation (AD) to scrutinize every element within variables (e.g., arrays) necessary for checkpointing. This allows us to ...

According to Sawyer Merritt, at Up.Summit 2025, Tesla's Optimus Robot exemplifies the 'first principles' methodology by deconstructing problems to their fundamental elements and rebuilding solutions ...

What if the secret to solving the world’s most complex problems wasn’t about thinking bigger, but thinking smaller, breaking things down to their most basic truths? This is the power of first ...

Single cell gene expression studies often rely on single-cell RNA sequencing (scRNA-seq) alone. While scRNA-seq reveals which genes are turned on, it does not capture protein expression or changes to ...

ABSTRACT: Equity and fairness are fundamental principles in climate negotiations under the UNFCCC, essential for incentivizing active and effective participation of all parties involved. Historically, ...

For stem cells to differentiate into the appropriate cell-type, transcription factors (TFs) must be tailored to highly specific expression patterns of lineage-specific genes. Abnormalities in the ...

Background: Obesity is a metabolic disease that is characterized by an excessive accumulation of adipose tissue (AT) and is often associated with other pathologies. AT is a lipid storage organ with ...

Abstract: Discovering dielectric materials with large flexoelectric coefficients is key to advancing electromechanical devices. Using first-principles calculations, we determine the longitudinal and ...

The segmentation of gastrointestinal (GI) organs, including the stomach, small intestine, and large intestine, is crucial for radio oncologists to plan effective cancer therapy. This study presents an ...