What keeps our cells the right size? Scientists have long puzzled over this fundamental question, since cells that are too large or too small are linked to many diseases. Until now, the genetic basis ...

Abstract: In the rapidly evolving field of consumer healthcare, the exploration of non-coding RNA interactions is crucial for drug development and personalized therapy. However, through traditional ...

tRNA-derived small RNAs (tsRNAs) are a class of non-coding RNAs that are generated by cleavage of precursors or mature tRNAs under stress conditions such as hypoxia, oxidative stress and nutrient ...

We’re celebrating 180 years of Scientific American. Explore our legacy of discovery and look ahead to the future. In 1957, just four years after Francis Crick and other scientists solved the riddle of ...

1 Department of Medicine, Division of Pulmonary and Critical Care Medicine, Boston University, Boston, MA, United States 2 Department of Biology and Chemistry, Changwon National University, Changwon, ...

The work provides important insights into how this lncRNA regulates gene expression via complex mechanisms, however, the biological relevance awaits validation in other models. This paper provides ...

The ELAV protein binds to specific regions of the precursor RNA, namely to so-called reverse complementary sequences (RCMs) in the introns flanking the "backsplice junction" (BSJ) that is crucial for ...

The Nature Index 2025 Research Leaders — previously known as Annual Tables — reveal the leading institutions and countries/territories in the natural and health sciences, according to their output in ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Herpesviruses require the host transcriptional ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 50 (December 13, 2022), pp. 1-12 (12 pages) R-loops, or RNA:DNA hybrids, can induce DNA damage, which ...

This is an important and convincing dataset shedding new light on a role for Malat1 in osteoblast physiology. The work is of value to areas other than the bone field because it supports a role and ...