This valuable study identifies a novel regulator of stress-induced gene quiescence in C. elegans: the multi-Zinc-finger protein ZNF-236. The work provides evidence for an active mechanism that ...

Nucleosomes are barriers to RNA Polymerase II (Pol II) transcribing along gene bodies in eukaryotes. We found that a fragile “tailless nucleosome” could be generated to resolve the Pol II pausing ...

RNA sequencing (RNA-Seq) is a high-throughput sequencing approach that enables comprehensive quantification of transcriptomes at a genome-wide scale. As a result, RNA-Seq has become a routine ...

Abstract: An average person usually contains more than 10 trillion human cells, and each cell's transcriptome can be profiled by a single-cell RNA sequence (scRNA-seq). The huge volume and high ...

LOS ANGELES--(BUSINESS WIRE)--#Biotech--Molecular Instruments® (MI), the inventor of the HCR™ platform, today announced key enhancements to its HCR™ Gold and HCR™ Pro product lines. These upgrades ...

aSchool of Basic Medical Sciences, Tsinghua University, 100084, Beijing, China bCentre for Life Sciences, Tsinghua University, 100084, Beijing, China cDepartment of Infectious Diseases, Peking Union ...

High background noise in RNA samples can impact read accuracy and increase sequencing costs. Optimizing sample quality enables better microRNA mapping and more reliable insights in transcriptomics and ...

This project develops a comprehensive and modular bulk RNA-sequencing (RNA-seq) analysis tool using RShiny. The suite consists of interconnected RShiny applications, each dedicated to a specific stage ...