Single-cell RNA sequencing (scRNA-seq) has profoundly reshaped our understanding of cellular diversity and functionality; however, accurate cell-type annotation is required for biological ...

Background Most patients with biliary tract cancer (BTC) do not derive durable clinical benefit (DCB) from immune checkpoint inhibitors (ICIs), underscoring the urgent need for predictive biomarkers.

Understanding cellular responses to chemical interventions is critical to the discovery of effective therapeutics. Because individual biological techniques often measure only one axis of cellular ...

scProca is a package designed to integrate and generate single-cell proteomics from transcriptomics, implemented in PyTorch. Overview of scProca. (A) Schematic representation of scProca within the ...

The liver is remarkable for its ability to regenerate after injury, yet when this process fails, acute liver failure (ALF) carries devastating outcomes. Traditional research methods, reliant on bulk ...

Initially, cells are dissociated from liver tissues into single-cell suspensions using in vivo enzymatic perfusion or ex vivo digestion methods. The cells of interest are then enriched from the ...

On August 21, the State Key Laboratory of Genome and Multi-omics Technologies, led by BGI-Research, collaborated with multiple institutions to unveil a groundbreaking single-cell omics technology ...

The liver is a highly multifunctional organ that can perform many metabolic and immunological functions due to a highly complex spatially organised microarchitecture that is disturbed in many liver ...

This manuscript presents an important contribution to the field of single-cell transcriptomic analysis in cancer by introducing a novel computational framework-SCellBOW-which applies embedding ...