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BCR-ABL Translocation in CML | Pathogenesis & Molecular Basis | Animated biology with Arpan
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BCR-ABL Translocation in CML | Pathogenesis & Molecular Basis | Animated biology with Arpan
Chronic Myelogenous Leukemia (CML) is a myeloproliferative disorder caused by the BCR-ABL fusion gene formed due to the Philadelphia chromosome translocation t(9;22). In this video, we clearly explain the molecular pathogenesis of CML, focusing on BCR-ABL tyrosine kinase activity, uncontrolled cell proliferation, and reduced apoptosis. This ...
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